VEGF和Ki-67在膀胱移行细胞癌中的表达和临床意义

摘要

目的 探讨膀胱移行细胞癌(BTCC)组织中血管内皮生长因子（VEGF）和Ki-67的表达和临床意义,研究二者与肿瘤血管形成和肿瘤细胞增殖的关系.方法 采用免疫组织化学SP法检测68例BTCC组织中VEGF和Ki-67的表达,分析VEGF和Ki-67表达与肿瘤病理分级、复发、转移及预后的关系.结果 BTCC组织中VEGF阳性率为73.53％,Ki-67阳性率为70.59％.在不同病理分级BTCC组织中VEGF和Ki-67的表达有明显差异,病理分级高的明显高于分级低的(P＜0.05)；浸润性肿瘤明显高于表浅性肿瘤(P＜0.05)；复发组均明显高于无复发组(P ＜0.05)；Ki-67和VEGF协同强阳性表达率差异有统计学意义(P＜0.01).结论 VEGF和Ki-67的阳性表达尤其是联合阳性表达对判断膀胱癌复发、评估预后具有重要意义.%Objective To investigate the expression and clinical significance of vascular endothelial growth factor(VEGF) and Ki-67 in bladder transitional cell cancer( BTCC)and to explore the correlation between VECF and Ki-67 in the angiogenesis of tumor and tumor cell proliferation. Methods The expressions of VEGF and Ki-67 were detected by immunohistochemical methods in 68 cases of BTCC. The correlation between the expression of VECF and Ki-67 and various clinicopathological parameters including pathological grade,recurrence, metastasis and prognostic evaluation were analyzed. Results The positive expression rates of VEGF and Ki-67 in 68 cases of BTCC were 73.53% and 70.59% respectively. There was a significant difference in VEGF and Ki-67 expression among differently pathological grade, and the positive rate in high grade was significantly higher than that in low grade ( P < 0. 05 ). The positive rate of the invasive tumor was significantly higher than that in superficial tumor ( P < 0. 05 ). The positive rate in recurrence group was significantly higher than that in non-recurrence group ( P < 0. 05 ). The combined positive rate difference of Ki-67-and VEGF had statistical significance( P0. 01). Conclusions The expression of VEGF and Ki-67, especially the positive combined expression plays an important role in the judgment of recurrence and prognostic evaluation.