目的探讨细胞周期相关蛋白p27在牙龈癌及口腔黏膜癌前病变组织中的表达及其临床病理学意义。方法应用SP免疫组化法检测21例正常黏膜组织、26例癌前病变（白斑、红斑）组织及46例牙龈癌组织中p27蛋白的表达水平，分析p27蛋白与牙龈癌的病理分级和临床分期的关系。结果 p27蛋白在正常口腔黏膜组织与癌前病变及牙龈癌组织中的阳性率和阳性表达率差异有统计学意义（P ＜0构．05），在正常口腔黏膜组织中的表达高于另2组p27蛋白的表达与患者性别、年龄等因素无相关性（ P ＞0．05），但与病变的临床分级及病理分期密切相关（ P ＜0．05）。结论 p27蛋白与癌前病变和牙龈癌的发生发展有密切关系，并与牙龈癌的临床分期成反比关系，与牙龈癌的病理分级成正比关系。%Objective To investigate the expression of cell cycle related protein p 27 in gingival cancer and oral precancerous lesions tissues as well its clinicopathological significance .Methods The experimental levels of p27 protein were detected by immunohistochemistry ( SP) in 21 cases of normal mucous membrane tissues ,26 cases of oral precancerous lesions tissues ( leukoplakia , erythema ) and 46 cases of gingival cancer tissues .The correlation between p27 protein and pathological classification , clinical stage of gingival cancer was analyzed . Results There were significant differences in the positive rates and positive expression rates among normal mucous membrane tissues,precancerous lesions tissues and gingival cancer tissues ( P <0.05).The expression levels of p27 protein in normal mucous membrane tissues were higher than those in the other two groups , which were not related with patient ’s gender and age ( P >0.05),however,which were closely correlated with clinical stage and pathological classification of gingival cancer ( P <0.05).Conclusion The p27 protein is closely related to the pathogenesis and development of precancerous lesions and gingival cancer , which is negatively correlated with clinical stage ,however ,which is positively related to pathological classification of gingival cancer .
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