Detection and Clinicopathologic Correlation of Human Immunodeficiency Virus (HIV-1) Nucleic Acids and Antigens in Reticuloendothelial and Central Nervous System Tissues, by Immunohistochemistry, in situ Hybridization, and Polymerase Chain Reaction.

摘要

The aim of this study was to determine the extent of histopathologic changes and presence of HIV-1 viral RNA throughout the lymphoid system in early HIV-1 disease. We found that a high percentage of lymphoid tissues demonstrate follicular hyperplasia with fragmentation and follicular involution characteristic of HIV-1 infection. Follicular fragmentation, involution or depletion are generally present throughout the lymphoid system and there is good concordance from one lymphoid site to another. Therefore, sampling of one lymph node group may be indicative of overall histopathologic pattern. Our data do not indicate that early HIV-1 related histopathologic changes are concentrated in certain lymphoid sites but suggest that HIV-1 infection is multicentric from an early stage of infection.