调节性T细胞在鼻息肉中的表达及意义

摘要

Objective To investigate the expression of Treg -related transcription factor ( Foxp3 ) and cytokine transforming growth factor ( TGF-β1 ) in patients with chronic sinusitis .Methods The immunohistochemical method (Elivision) was used to detect the expression levels of Foxp3 and TGF-β1 in 20 cases of nasal polyps tissues,15 cases of polyps surrounding tissues ,20 cases of ethmoid sinus mucous membrane tissues of chronic sinusitis and 10 cases of normal inferior turbinate mucous membrane tissues ( control group ) .Results The expression levels of Foxp 3 in nasal polyps tissues were significantly lower than those in the other three groups ( P <0.05),there were significant differences between any two groups ( P <0.05),except between polyps surrounding tissues and ethmoid sinus mucous membrane tissues ( P >0.05). The expression levels of TGF-β1 in nasal polyps tissues were lower than those in control group , however , which in ethmoid sinus mucous membrane tissues of chronic sinusitis were higher than those in control group .There were significant differences between any two groups ( P <0.05),except between polyps surrounding tissues and ethmoid sinus mucous membrane tissues ( P >0.05).Conclusion Foxp3 plays an important role in the pathogenesis and development of nasal polyps ;TGF-β1 plays an important role in different types of chronic sinusitis .%目的：探讨慢性鼻窦炎患者中调节性T细胞（Treg）相关转录因子叉头转录因子（Foxp3）及细胞因子转录生长因子β1（TGF-β1）的表达情况。方法采用免疫组织化学Elivision方法检测Foxp3、TGF-β1在20例鼻息肉组织、15例息肉周围组织、20例慢性鼻窦炎筛窦黏膜组织和10例正常下鼻甲黏膜组织中的表达。结果 Foxp3在鼻息肉组织中的表达明显低于其他3组（ P ＜0%．05），两两比较除息肉周围组与筛窦黏膜组比较差异无统计学意义（ P ＞0．05）外其他均有统计学意义（ P ＜0．05），TGF-β1在鼻息肉组织中的表达低于对照组，而在慢性鼻窦炎筛窦黏膜组织中的表达高于对照组，两两比较除息肉周围组与筛窦黏膜组比较差异无统计学意义（ P ＞0．05）外其他均有统计学意义（ P ＜0．05）。结论 Foxp3在鼻息肉的发生发展过程中发挥重要的作用；TGF-β1在不同类型的慢性鼻窦炎中发挥不同的作用。