桃红四物汤治疗心血瘀阻型稳定性冠心病的临床疗效

摘要

Objective To observe the clinical effects of Taohong-siwu decoction on the treatment of stable coronary heart disease with blood stasis type.Methods 144 patients with coronary heart disease were randomly divided into two groups.The control group (n=72) was treated by western routine therapy.The treatment group (n=72) was treated by Taohong-siwu decoction on the basis of control group, the treatment course was 90 d in two groups.The scores of traditional Chinese medicine (TCM) syndrome and seattle angina questionnaire (SAQ) before and after treatment were compared in two groups.The curative effects of TCM syndrome in two groups were compared to analyze the correlation between TCM syndrome and quality of life.Results The scores of TCM syndrome after treatment 30 d, 60 d, 90 d were decreased in two groups (P<0.05), and which in treatment group were lower than those in control group at the same period (P<0.05, P<0.01).The scores of SAQ after treatment were increased in two groups (P<0.05).The scores of body limited degree and anginal stability after treatment 30 d in treatment group were higher than those in control group (P<0.05).In addition to anginal frequency, the other four dimension scores in treatment group were higher than those in control group at the same period (P< 0.05, P< 0.01).The scores of body limited degree, anginal stability, anginal frequency, satisfaction with treatment and disease perception after treatment 90 d in treatment group were higher than those in control group at the same period (P< 0.05, P< 0.01).The total effective rate in treatment group (89.23%) was superior to that in control group (71.64%, P<0.05).The efficacy of TCM syndrome in treatment group was better than that in control group.The more the TCM syndrome scores improved, the more the quality of life improved.Conclusion Taohong-siwu decoction was better than western routine therapy on improvement of TCM syndrome and quality of life for stable coronary heart disease with blood stasis type, and the quality of life is positively correlated with the improvement of TCM syndrome.%目的 观察桃红四物汤治疗心血瘀阻型稳定性冠心病的临床疗效.方法 将144例心血瘀阻型稳定性冠心病患者随机分为2组,对照组72例应用西医常规治疗,治疗组72例在对照组治疗基础上应用桃红四物汤治疗,2组疗程90 d.比较2组治疗前后中医证候积分、西雅图量表(SAQ)积分变化,比较2组中医证候疗效,分析中医证候与生活质量的相关性.结果 2组治疗30、60、90 d中医证候积分均较本组治疗前降低(P<0.05);且治疗组中医证候积分均低于对照组治疗同期(P<0.05,P<0.01).2组治疗后SAQ积分均较本组治疗前升高(P<0.05);治疗组治疗30 d,躯体受限程度、心绞痛稳定状态积分均高于对照组治疗同期(P<0.05);治疗组治疗60 d除心绞痛发作情况外,其他4个维度积分较高于对照组治疗同期(P<0.05,P<0.01);治疗组治疗90 d,躯体受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度、疾病认识程度积分均高于对照组治疗同期(P<0.05,P<0.01).治疗组总有效率89.23%,对照组71.64%,2组总有效率比较差异有统计学意义(P<0.05),治疗组中医证候疗效优于对照组.中医证候积分改善越多,生活质量就改善越多.结论 桃红四物汤在对心血瘀阻型稳定性冠心病患者的中医证候、生活质量的改善方面优于常规西医治疗,生活质量与中医证候的改善呈正相关.