目的 探讨关节内注射玻璃酸钠治疗早期髌骨软化症的疗效及可行性.方法 选择2006年12月至2010年12月江门市中心医院和南方医院门诊部收治的髌骨软化症患者76例,按照患者意愿分为A组(口服美洛昔康)24例,B组(口服美洛昔康+关节注射玻璃酸钠)32例和C组(关节注射玻璃酸钠)20例.比较三组患者治疗前后关节功能和疼痛变化情况.结果 B组镇痛效果好,与A、C组差异有统计学意义(P＜0.05,P＜0.01),A、C组相比差异无统计学意义(P＞0.05)；B、C组关节功能改善好,与A组比较差异有统计学意义(P＜0.05,P＜0.05),B、C组比较差异无统计学意义(P＞0.05).结论 关节内注射玻璃酸钠利于软骨修复,改善关节功能,镇痛效果与非甾体消炎药相当,可作为早期髌骨软化症治疗的有效方法.%Objective To evaluate the feasibility of joint injection of sodium hyaluronate for treating chon-dromacia patellae at early stage. Methods Seventy-six patients admitted in Central Hospital of Jiangmen city and Nanfang Hospital of Guangzhou City from Dec. 2006 to Dec. 2010 were divided into three groups. Patients in group A received oral NSAIDs (n=24), those in group B was treated by oral NSAIDs plus joint injection of sodium hyaluronate, and those in group C received joint injection of sodium hyaluronate. Comparison was made in joint function and joint pain between the three groups before and after treatment. Results The efficacy of pain relief in group B was significantly superior to that in group A and group C (P<0.05, P<0.05). No statistically significant difference was found between group A and C (P>0.05). The improvement of joint function in group B and group C was significantly superior to that in group A (P<0.05, P<0.05). No statistically significant difference was found between group B and C (P> 0.05). Conclusion Joint injection of sodium hyaluronate could repair articular cartilage, increase joint function and relieve pain as good as NSAIDs, which could be used for patients with chondromacia patellae at early stage.
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