Objective To observe the therapeutic efficacy of rh-EGF on small area deep second-degree bum wounds in children. Methods 92 patients suffered from small area deep second-degree bum wounds, all the patients were randomly divided into three groups. Silver sulfadiazine (Group A), b-FGF-ESSEX (Group B) and rh-EGF (Group C) were used as topic agents respectively. Their efficacy were observed and compared. Results All the 92 patients were clinical recovered. The average healing time of Group A was (20±2.4) d, Group B was (17±3.1 ) d, Group C was (15±2.6) d. The wound area was gradually dwindled with the treatment time expand, The healing speed in Group C was faster than those in Group A and Group B. Recovering after 6 months and 12 months, the scar index in Group C was superior to that in Group A and Group B. Conclusion Compared with silver sulfadiazine and b-FGF-ESSEX, rh-EGF can reduce the healing time of children small area deep second-degree bum wounds, with the superior scar index.%目的 观察重组人表皮细胞生长因子(Recombinant human epithelial growth factor,rh-EGF)对儿童小面积深Ⅱ度烧烫伤的疗效.方法 采用随机对照试验方法,选择92例儿童小面积深Ⅱ度烧烫伤病例,随机分为三组治疗.A组:1%SD-Ag冷霜治疗组;B组:贝复济(b-FGF-ESSEX)治疗组,C组:rh-EGF治疗组.观察创面愈合速率及创面愈合后6个月及12个月瘢痕指数(SD.结果 92例患儿经治疗后全部临床愈合,A组平均愈合时间为(20±2.4)d,B组平均愈合时间为(17±3.1)d,C组(15±2.6)d.治疗过程中各组创面面积随治疗时间延长而逐渐缩小,C组愈合速率明显快于A、B组.创面愈合6个月、12个月后随访,c组的SI优于A、B两组.结论 rh-EGF治疗儿童小面积深Ⅱ度烧烫伤患儿,创面愈合速率及SI优于SD-Ag冷霜治疗组和贝复济治疗组.
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