血清中葡萄糖6磷酸异构酶阳性的中国汉族类风湿关节炎的临床特点

摘要

To explore the clinical significance of glucose-6-phosphate isomerase (GPI) in Chinese Hah patients with rheumatoid arthritis (PA). Methods Serum samples obtained from 283 Chinese Hah PA patients was assayed for glucose-6-phosphate isomerase by ELISA and the relationship between the GPI and the disease activity was studied. Results Prevalence of GPI was 80.04％ in Chinese Hah PA patients, and the younger age and higher Disease activity score (DSA28) were found in GPI-positive group than those in GPI-negative group. Conclusion GPI was helpful for diagnosis of PA in Chinese Han population. The GPI-positive PA patients were often relatively younger and had higher disease activity.%目的 探讨血清中葡萄糖6磷酸异构酶(GPI)阳性的中国汉族类风湿关节炎(RA)的临床特点.方法 用酶联免疫吸收法(ELISA)在283例中国汉族RA患者中对GPI进行了测定,并分析GPI与RA临床表现和其他辅助检查结果之间的关系.结果 GPI在中国汉族RA患者中的阳性率为83.04%,与GPI阴性的RA患者相比,GPI阳性的RA患者的起病年龄较轻[(394±15)岁vs(51±18)岁,P＜0.05)],28处关节疾病活动度积分(DAS28)较高[(3.772±0.281)分vs(2.783±0.564)分,P＜0.05)].结论 GPI在中国汉族RA患者的阳性率较高,有助于RA的筛查.血清中GPI阳性的RA患者的起病年龄相对较轻,病情活动性较高.