高敏肌钙蛋白T轻度升高的胸痛患者冠脉造影分析

摘要

目的 探讨高敏肌钙蛋白T(hsTnT)轻度升高在胸痛患者鉴别诊断中的作用.方法 2010年1月1日至2010年9月30日就诊于我院的胸痛患者,hsTnT水平在0.001～0.030 ng/ml者,根据冠脉造影结果分为冠心病组和非冠心病组.hs-TnT检查采用美国罗氏公司的cobas e601自动检测仪检测.结果 共入选45名患者,两组患者年龄、性别、肌酐清除率差异无统计学意义,冠心病组hsTnT较非冠心病组升高,分别为(0.014±0.009)ng/ml和(0.007+0.005)ng/ml,P=0.004.冠心病组患者hsTnT与冠脉Gensini积分相关分析:相关系数r=0.418,P=0.034.结论 对于疑诊冠心病的胸痛患者,低浓度的hsTnT升高有助于冠心病的诊断,且hsTnT的值可能与冠脉病变的范围和程度有关.%Objective To analyze the results of coronary angiography in patients with chest pain and mildly elevated high sensitive cardiac tropoin T. Methods From Jan-1-2010 to Sep-30-2010, inpatients with chest pain and hsTnT among 0.001-0.030ng/ml were included in our study. All these patients were divided into coronary disease group and non-coronary disease group based on the results of coronary angiography. HsTnT was accessed by cobas e601 marketed by Roche Diagnostics. Results 45 patients were included in this study. No difference was found in age, sex or creatinine clearance rate between these two groups. While hsTnT in the coronary group was higher than that in the non-coronary group (0.014±0.009 ng/ml vs 0.007 ± 0.005 ng/ml, P=0.004). HsTnT value in the coronary group was correlated to Gensini score (r=0.418, P=0.034). Conclusion In patients with chest who were suspected of coronary artery disease, mildly elevated hsTnT could indicate the presence of coronary artery disease. Elevated hsTnT might be related to the extent and severity of coronary lesions.