G6PD缺陷症对新生儿高胆红素血症病程的影响

摘要

目的 探讨G6PD缺陷症对新生儿高胆红素血症病程的影响.方法 确诊高胆红素血症新生儿77例,分为两组:G6PD缺陷症组37例,G6PD正常组40例.全部病例均给予双面蓝光光疗,对比两组新生儿治疗前血清总胆红素(Total serum bilirubin,TSB)、血红蛋白和治疗后TSB、血红蛋白、总光疗时间、住院天数.结果 G6PD缺陷症组和G6PD正常组新生儿治疗前TSB分别为(278.43±15.26) μmol/L和(276.68±12.15) μmol/L(P＞0.05),血红蛋白分别为(165.58+10.90) g/L和(160.95±9.76) g/L (P＞0.05).G6PD缺陷症组和G6PD正常组新生儿治疗后TSB分别为(168.70±9.79) μmol/L和(162.68±12.09) μmol/L (P＜0.05),血红蛋白分别为(150.59±7.82) g/L和(153.63±7.80) g/L(P＞0.05).G6PD缺陷症组和G6PD正常组新生儿总光疗时间分别为(65.51 ±16.87)h和(45.00±12.67)h (P＜0.01),住院天数分别为(7.22±1.60)d和(5.58±1.45)d (P＜0.01).结论 G6PD缺陷症新生儿虽无明显溶血发生,但G6PD缺乏也会延缓高胆红素血症的消退,增加光疗时间和住院天数.%Objective To observe the influence of G6PD deficiency on the course of neonatal hyperbilirubi-nemia. Methods Seventy-seven neonates with hyperbilirubinemia were divided into G6PD deficient group (n=37) and G6PD normal group (n=40). All the neonates were gave phototherapy in double-side blue light. Before and after phototherapy, the total serum bilirubin (TSB) and hemoglobin were respectively detected. The levels of TSB, hemoglobin, phototherapy hours and length of hospital stay were compared between the two groups. Results Before phototherapy, the levels of TSB for the G6PD deficient group and G6PD normal group was (278.43± 15.26) μmol/L and (276.68±12.15) umol/L, respectively (P<0.05), and the levels of hemoglobin was (165.58±10.90) g/L and (160.95± 9.76) g/L, respectively (P<0.05). After phototherapy, the levels of TSB for the two groups was (168.70±9.79) umol/L and (162.68±12.09) μmol/L, respectively (P<0.05), and the levels of hemoglobin was (150.59±7.82) g/L and (153.63± 7.80) g/L, respectively (P<0.05). The phototherapy hours for the two groups were (65.51±16.87) h and (45.00±12.67) h, respectively (P<0.01), and the length of hospital stay was (7.22±1.60) d and (5.58±1.45) d, respectively (P<0.01). Conclusion Even though resulting in no haemolysis, G6PD deficient can delay the decrease of the TSB in neonates and increase phototherapy hours and the length of hospital stay.