类风湿性关节炎患者血清IL-6、TNF-α、CRP的水平变化及意义

摘要

目的 探讨类风湿性关节炎患者血清IL-6、TNF-α、CRP的水平变化及临床意义.方法 采用酶联免疫吸附法(ELISA)及免疫比浊法对74例RA患者(RA活动期组48例、RA非活动期组26例)血清IL-6、TNF-α、CRP水平进行检测,并与30例正常对照组的健康受试者进行比较分析.结果 RA组患者血清IL-6 [(8.03±0.98)pg/L]、TNF-α [(7.54±0.82)pg/L]、CRP[(11.40±1.25)mg/L]等检测指标水平显著高于正常对照组,差异均具有统计学意义(均P＜0.05)；RA活动期组患者血清IL-6[(10.42±1.51 )pg/L]、TNF-α[(10.32±1.34)pg/L]、CRP[(15.02±1.8 1)mg/L]等检测指标水平显著高于非活动期组,差异亦均具有统计学意义(均P＜0.05)；RA患者血清IL-6、TNF-α水平呈正性显著相关(r=0.61,P＜0.05); IL-6、TNF-α.与CRP水平呈正性显著相关(r=0.52,r=0.71,均P＜0.05).结论 检测RA患者血清IL-6、TNF-α与CRP水平对观察其病情变化具有重重的临床价值.%Objective To explore the clinical significance of detecting serum levels of IL-6, TNF-α, CRP in patients with rheumatoid arthritis (RA). Methods The serum levels of IL-6, TNF-a, CRP were detected in 74 patients with RA (RA group), including 48 patients with active RA (active RA group), 26 patients with inactive RA (inactive RA group) by enzyme-linked immunosorbent assays (ELISA) and immunoturbidimetry, and compared with those of 30 healthy subjects (the control group). Results The serum levels of IL-6 [(8.03±0.98) pg/L], [TNF-a (7.54±0.82) pg/L], [CRP (11.40±1.25) mg/L] in the RA group were significantly higher than those in the control group (all with P<0.05). The serum levels of IL-6 [(10.42±1.51) pg/L], TNF-a [(10.32±1.34) pg/L], [CRP (15.02±1.81) mg/L] in the active RA group were significantly higher than those in the in active RA group (all with P<0.05). The serum levels of IL-6 was positively correlated with TNF-a (r=0.61, P<0.05), and the serum levels of IL-6 and TNF-a were positively correlated with CRP (r=0.52, r=0.71, all P<0.05). Conclusion The detection of serum levels of IL-6, TNF-α and CRP are all sensitive in observing the change of diseases in patients with RA.