目的 探讨结直肠癌术后腹腔引流液中肿瘤标志物CEA、CA125、CA19-9浓度与肿瘤淋巴结转移的相关性.方法 检测55例结直肠癌患者术后第1、2天腹腔引流液中肿瘤标志物CEA、CA125、CA19-9的浓度,并按照有无淋巴结转移进行分组.结果 术后第1、2天无淋巴结转移组与有淋巴结转移组腹腔引流液中CEA浓度比较差异有统计学意义,无淋巴结转移组CEA浓度低于有淋巴结转移组,CA19-9、CA125浓度比较差异无统计学意义；无淋巴结转移组第1、2天腹腔引流液CEA、CA125浓度比较差异有统计学意义,第2天CEA浓度低于第1天,CA125浓度高于第1天,CA19-9比较差异无统计学意义；有淋巴结转移组术后第1、2天腹腔引流液中CEA、CA19-9、CA125浓度比较差异无统计学意义.结论 结直肠癌患者术后早期腹腔引流液中CEA浓度的表达与肿瘤的淋巴结转移具有正相关性,而CA19-9和CA125临床价值不大.%Objective To investigate the levels of tumor markers (CEA, CA125, CA19-9) in intraperitoneal drainage after resection of colorectal cancer, and their relationship with lymph node metastasis. Methods Fifty pa tients with colorectal cancer were enrolled in this study. The levels of tumor markers (CEA, CA125, CA19-9) were de tected on the first, second day after resection. The patients were divided into two groups: group A (with lymph node metastasis) and group B (without lymph node metastasis). Results After resection, the levels of CEA was significant ly higher in group A than group B, and the levels of CA19-9 and CA125 showed no statistically significant difference between the two groups. In group B, the levels of CEA was significantly higher on the first day than the second day af ter resection, and the levels of CA125 was significantly lower on the first day, with no statistically significant differ ence in the levels of CA19-9. In group A, the levels of CEA, CA19-9, CA125 showed no statistically significant dif ference between the first day and the second day. Conclusion The levels of CEA in intraperitoneal drainage after re section in patients with colorectal cancer is positively correlated with lymph node metastasis, while CA19-9 and CA125 have little clinical value.
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