Objective To observe the relationship between resistin and left ventricular hypertrophy (LVH) in patients with hypertension. Methods Sixty-seven patients were divided into HTN group (hypertension) and the LVH group (hypertension complicated with left ventricular hypertrophy group). Thirty healthy individuals were selected as the control group. Blood pressure (BP), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and resistin were measured. Results (1) IVST [(13.31±2.07) mm vs (10.47±1.48) mm], LVPWT [(12.79±2.01) mm vs (10.68 ±1.51) mm], LVMI [(142.26±6.39) g/m2 vs (118.65±4.84) g/m2] in the LVH group were significantly increased than those in the HTN group ( P<0.05). (2) Resistin level was significantly different between the HTN group [(0.78±0.16) μg/L] and the LVH group [(1.02±0.31) μg/L], both of which were significantly higher than that in the control group [(0.53±0.11) μ.g/L, P<0.05]. Conclusion Resistin is correlated to LVH, which can be used as target for prevention and treatment of LVH.%目的 观察高血压病并左室肥厚(LVH)患者血清抵抗素水平的改变,探讨抵抗素与LVH的相关性.方法 选择临床高血压患者67例,其中单纯高血压组(HTN组)35例,LVH组32例,另外选择30例健康人为正常对照组.所有入选患者均在入选后测定血压(BP)、室间隔厚度(IVST)、左室后壁厚度(LVPWT)、左室质量指数(LVMI)和血清抵抗素水平.结果 (1)LVH 组与HTN 组比较,IVST [(13.31±2.07) mm vs (10.47±1.48) mm]、LVPWT [(12.79±2.01) mm vs (10.68±1.51) mm]、LVMI [(142.26±6.39)g/m2 vs(118.65±4.84)g/m2]均明显增加(P<0.05).(2) HTN组和LVH组患者的血清抵抗素水平分别为(0.78±0.16) μg/L和(1.02±0.31) μg/L,均明显高于正常对照组的(0.53±0.11) μg/L,P<0.05,而LVH组血清抵抗素水平又高于HTN组[(1.02±0.31) μg/L vs 0.78±0.16) μg/L,P<0.05] 结论血清抵抗素与LVH相关,可以作为临床预防和治疗LVH的靶点.
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