老年患者腹部手术后BNP的变化及其与心力衰竭的关系探讨

摘要

Objective To investigate the changes of B-type natriuretic peptide in geriatric patients after abdominal operation and its relationship with post-operational heart failure. Methods Using chemiluminescence immunoassay to monitor the levels of B-type natriuretic peptide in geriatric patients after abdominal operation, and to divide groups with its levels and observe the incidences of post-operational heart failure in different groups. Results The incidence of heart failure in patients with BNP levels above 400 pg/ml increased significantly than that in patients with BNP levels below 400 pg/ml. BNP level reduced significantly after effective treatment of heart failure. Conclusion The changes of B-type natriuretic peptide in geriatric patients after abdominal operation are closely related with post-operational heart failure. It is efficient to prevent heart failure in geriatric patients post abdominal operation by means of dynamically monitoring the changes of B-type natriuretic peptide.%目的 探讨B型钠尿肽(BNP)在老年患者腹部外科手术后的变化情况及其与术后心力衰竭的关系.方法 采用化学发光免疫法动态监测64例老年患者腹部手术后BNP水平的变化,并按术后BNP水平分组,观察各组患者心力衰竭发生的概率.结果 BNP水平≥400 pg/ml的患者心力衰竭的发生概率较BNP水平＜400 pg/ml的患者明显升高；经积极治疗后BNP水平显著下降.结论 老年患者腹部手术后BNP水平与心力衰竭的发生密切相关,动态监测BNP水平能有效防治老年患者腹部手术后心力衰竭.