冠心病患者血清IL-1ra和IL-6水平与冠脉病变程度及预后的相关性研究

摘要

Objective To explore the correlation between serum I-1 receptor antagonist (IL-1ra), interleu-kin-6 (IL-6) levels of patients with coronary heart disease and severity of coronary artery disease and prognosis. Methods One hundred and ninety-eight patients who were suspected for coronary artery disease and underwent coro-nary angiography from February 2009 to November 2012 were selected. According to the degree of coronary artery le-sions, the patients were divided into CHD group (n=168) and control group (n=30). Serum lipids, IL-1ra and IL-6 lev-els of two groups were detected, and the relationships between the number of coronary lesions, Gensini score and IL-1ra, IL-6 levels were analyzed. The risk of major cardiovascular events in different IL-1ra and IL-6 level groups were analyzed. Results Serum IL-1ra and IL-6 levels of CHD group were significantly higher than control group (P<0.05). There was significant difference among different branches of coronary artery disease in serum IL-1ra and IL-6 levels (P<0.05), and the more branches, the higher the level of serum IL-1ra and IL-6. Positive correlation was found between serum IL-1ra and IL-6 levels with Gensini score (r=0.79, P<0.05; r=0.75, P<0.05). The risk of major cardiovascular events in IL-1ra and IL-6 as three of the patients within 1 year increased significantly compared with the control group, the OD values were 5.40 (95% CI 1.46~20.01) and 5.82 (95% CI 1.58~21.54) (P<0.05). Conclusion IL-1ra and IL-6 are involved in the generation and development of coronary atherosclero-sis in patients with coronary heart disease. Their levels are correlated with the severity of coronary artery disease and the occurrence of major cardiovascular events during the year.%目的：探讨冠心病患者血清IL-1ra和IL-6水平与冠脉病变程度及预后的相关性。方法选择2009年2月至2012年11月疑为冠心病而入院行冠状动脉造影患者198例，根据冠脉病变程度分为冠心病组(n=168)及正常对照组(n=30)，检测两组血脂及血清IL-1ra和IL-6水平，分析其与冠脉病变支数、Gensini评分的关系。分析冠心病组不同IL-1ra和IL-6等级发生主要心血管事件的风险。结果冠心病组患者血清IL-1ra和IL-6水平显著高于对照组患者(P<0.05)。不同病变冠脉支数患者血清IL-1ra和IL-6水平差异均具有统计学意义(P<0.05)，支数越多的患者血清IL-1ra和IL-6水平越高。冠心病组患者血清IL-1ra和IL-6水平与Gensini积分之间均存在正相关(r=0.79，P<0.05；r=0.75，P<0.05)。IL-1ra和IL-6为3级的患者1年内发生主要心血管事件的风险均较对照组显著增加，其OD值分别为5.40(95%CI 1.46~20.01)和5.82(95%CI 1.58~21.54)(P<0.05)。结论 IL-1ra和IL-6参与了冠心病患者冠状动脉粥样硬化的发生与发展，其水平与冠状动脉病变程度及1年内主要心血管事件发生有关。