血浆IL-17水平与颈动脉内中膜厚度的相关性研究

摘要

Objective To study the relationship between the level of interleukin-17 (IL-17) in the plasma and the intima-media thickness (IMT) of carotid artery in patients of essential hypertension complicated with carotid atherosclerosis. Methods In this study, 220 hypertensive patients were categorized into three groups by IMT:plaque group (essential hypertension with carotid artery plaque, 96 patients), thickening group (essential hypertension with ca-rotid artery thickening, 61 patients), normal group (essential hypertension with normal carotid artery, 63 patients). The control group included 61 non-hypertensive patients with normal carotid artery. The fasting periphery blood and the centrifugal upper plasma were collected from hypertensive groups and the control group to test the plasma level of IL-17 by using enzyme linked immunosorbent assay (ELISA). The correlation between the levels of IL-17 from all groups and carotid IMT were compared respectively. Results (1) The level of IL-17 was (401.850 ± 111.137) pg/ml in plaque group, (272.018±2.373) pg/ml in thickening group, (195.864±64.001) pg/ml in normal group, and (25.509± 7.721) pg/ml in the control group, which reduced successively, with statistically significant difference (all P=0.000, P<0.001). (2) Correlation analysis showed that the level of IL-17 was positively related to IMT by (r=0.732, P<0.001). Conclusion The plasma level of IL-17 is positively related to IMT in patients of essential hypertension complicated with carotid atherosclerosis.%目的：探讨原发性高血压并颈动脉硬化患者血浆中白细胞介素-17(IL-17)水平与颈动脉内中膜厚度(IMT)的相互关系。方法选取原发性高血压患者220例，行颈动脉彩超检查，根据颈动脉内中膜厚度分组，原发性高血压并颈动脉斑块组(斑块组)96例，原发性高血压并颈动脉增厚组(增厚组)61例，原发性高血压并颈动脉正常组(正常组)63例，对照组61例。采集所有研究对象的血浆，采用酶联免疫吸附法(ELISA)测定其血浆中IL-17浓度，比较血浆IL-17水平与IMT的相关性。结果(1)血浆IL-17水平在斑块组为(401.850±111.137) pg/ml、增厚组为(272.018±82.373) pg/ml、正常组为(195.864±64.001) pg/ml和对照组为(25.509±7.721) pg/ml，血浆IL-17水平依次降低，差异具有显著统计学意义(均P=0.000，P<0.001)；(2)相关分析显示血浆IL-17水平与IMT呈正直线相关(r=0.732，P<0.001)。结论原发性高血压并颈动脉硬化患者血浆IL-17与颈动脉内中膜厚度呈正相关。