水化对肾灌注造影患者造影剂肾病的影响

摘要

目的：观察水化对冠状动脉造影患者肾功能的影响。方法收集2011年9月至2013年8月2型糖尿病（T2DM）患者25例，应用低渗非离子型造影剂进行肾灌注造影，造影前及造影后第1、3天分别测定患者的血葡萄糖、24 h尿微量白蛋白、24 h尿蛋白定量、血尿素氮、血肌酐等各项指标，评价造影剂肾病的发生情况及肾功能的变化情况。结果 T2DM患者灌注造影后均未发生CIN。造影灌注后第1、3天24 h微量白蛋白、24 h蛋白定量、血尿素氮、血肌酐与造影前比较差异均无统计学意义(P>0.05)。结论加强水化能减轻肾功能伤害，减少造影剂肾病的发生率。%Objective To observe the effects of hydration on renal function in patients undergoing renal per-fusion imaging. Methods Twenty-five patients of type 2 diabetes mellitus (T2DM) admitted into our hospital from Sep. 2011 to Aug. 2013 were recruited in this study. The low osmolar and nonionic contrast media was used in all pa-tients. The blood glucose, 24 h urinary albumin, 24 h urinary protein, blood urea nitrogen, creatinine and other indica-tors of the patients were detected before imaging, 1 day and 3 days after imaging. The incidence of contrast-induced nephropathy and renal function changes were evaluated. Results No patient suffered contrast-induced nephropathy (CIN) after perfusion imaging. The 24 h urinary albumin, 24 h urinary protein, blood urea nitrogen and creatinine didn't have significant changes before imaging, 1 day and 3 days after imaging (P>0.05). Conclusion The strength-ened hydration therapy can reduce the renal damage and effectively prevent contrast-induced nephropathy.