红细胞分布宽度检测在妊娠期高血压疾病中的应用

摘要

Objective To explore the correlation between red blood cell distribution width (RDW) and preg-nancy hypertension disease (PHD).Methods The clinical data of 204 pregnant women in our hospital from Jan.2011 to Dec.2013 (68 normal pregnant women and 136 pregnant women of PHD) were retrospectively analyzed.The RDW values in different gestational time (20th week,24th week,28th week in pregnancy) were detected.Logistic regres-sion analysis was applied to explore the correlation between RDW and PDH.Receiver operating characteristic (ROC) curve was used to analyze the clinical value of RDW in the prediction of PHD.Results RDW in the same gestational time showed statistically significant differences between different pregnant women groups (P<0.05),while RDW in the same pregnant women group had no statistically significant difference in different gestational time (P>0.05).Logistic re-gression analysis showed that RDW was a risk factor for PHD (β=1.153,P<0.05).In ROC curve,the optimal threshold was 13.1 for predicting PHD by RDW,with sensitivity of 72.5%and specificity of 77.9%.Conclusion RDW,as a new chronic inflammatory mediator,is a high-risk factor of PHD,which has high clinical value in the prediction of PHD.%目的 探讨红细胞分布宽度(RDW)与妊娠期高血压疾病(PHD)之间的相关性.方法 采用回顾性研究的方法收集2011年1月至2013年12月孕妇204例,其中正常孕妇68例,PHD孕妇136例.检测妊娠中期不同时间点(20周、24周和28周)的RDW值.Logistic回归分析RDW与PDH发生的相关性,ROC曲线法分析RDW预测PHD发生的临床价值.结果 RDW在不同妊娠妇女人群的同一时间点比较差异均有统计学意义(P<0.05),而在同一妊娠妇女人群的三个不同时间点比较差异均无统计学意义(P>0.05).Logistic回归分析表明RDW是孕妇发生PHD的危险因素(β=1.153,P<0.05),ROC曲线得到RDW预测PHD的最佳临界值是13.1,灵敏度和特异度分别为72.5%和77.9%.结论 RDW作为一种新的慢性炎症介质,是PHD发生的一个高危因素,在预测PHD的发生中有较高的临床价值.