Objective To investigate the detection and clinical significance of non-myelinated nerve associat-ed proteins in cerebrospinal fluid (CSF) and serum of patients with relapsing-remitting multiple sclerosis (RRMS). Methods Seventy patients with RRMS in our hospital from January 2010 to December 2014 were enrolled as the ob-servation group, and 70 healthy people in our hospital for health examination at the same period were considered as the control group. The levels of non-myelinated nerve associated proteins (including 14-3-3 protein, S100 protein and tau protein) were analyzed and compared between the two groups. Results The levels of 14-3-3 protein, S100 pro-tein and tau protein in cerebrospinal fluid in the observation group were significantly higher than those in the control group (P<0.05), but the levels of the proteins in serum showed no statistically significant difference between the two groups (P>0.05). Conclusion The levels of non-myelinated nerve associated proteins in cerebrospinal fluid are sig-nificantly increased in patients with relapsing-remitting multiple sclerosis, which can be used as indicators of the dis-ease. However, the levels showed no significant change in serum of the patients.%目的 探讨复发缓解型多发性硬化(RRMS)患者脑脊液及血清中非髓鞘神经相关蛋白的水平及其临床意义.方法 选择2010年1月至2014年12月我院收治的70例RRMS患者作为观察组,同期来我院体检的70例健康体检者作为对照组,分别比较两组受试者的脑脊液与血清中的非髓鞘神经相关蛋白水平(包括14-3-3蛋白、S100蛋白及tau蛋白).结果 观察组患者脑脊液中的14-3-3蛋白、S100蛋白及tau蛋白水平均较对照组高,两组比较差异均有统计学意义(P<0.05);观察组患者血清中的14-3-3蛋白、S100蛋白及tau蛋白水平分别与对照组比较,差异均无统计学意义(P>0.05).结论 复发缓解型多发性硬化患者脑脊液中14-3-3蛋白、S100蛋白及tau蛋白非髓鞘神经相关蛋白均有明显升高现象,可以作为该病的检查指标,而血清中非髓鞘神经相关蛋白则无明显变化.
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