结肠癌组织中Cofilin-1蛋白的表达及临床病理意义

摘要

目的 探讨结肠癌组织中Cofilin-1蛋白的表达及其与肿瘤侵袭和转移的关系.方法 应用免疫组织化学SP法检测60例结肠癌组织、40例癌旁正常组织、26例转移淋巴结组织标本中Cofilin-1蛋白的表达水平,并结合临床病理参数进行分析.结果 Cofilin-1蛋白在结肠癌组织、转移淋巴结组织中表达率分别为76.7%、61.5%,均明显高于癌旁正常组织中的32.5%表达率.Cofilin-1在结肠癌组织、转移淋巴结组织中的表达率明显高于癌旁正常组织,差异均有统计学意义(P<0.05);Cofilin-1蛋白的表达水平与结肠癌组织分化程度、Dukes分期、浆膜侵犯及淋巴结转移有关(P<0.05),而与性别、年龄、肿瘤大小无明显相关(P>0.05);Cofilin-1与结肠癌预后密切相关(P<0.05).结论 检测Cofilin-1蛋白的表达有助于判断结肠癌的浸润、转移及预后.%Objective To investigate the expression of Cofilin-1 protein and its clinicopathological signifi-cance in colonic cancer. Methods The expression of Cofilin-1 protein in 60 colonic cancer specimens, 40 adjacent normal tissues, 26 lymph node metastasis tissues was detected by SP method. Meanwhile, the relationship between the expression of Cofilin-1 and the clinical pathologic factors was analyzed. Results The positive rate of Cofilin-1 expres-sion was 76.7%in colonic cancer specimens, 61.5%in lymph node metastasis tissues, which were significantly higher than 32.5% in adjacent normal tissues (P<0.05). Positive expression of Cofilin-1 protein was significantly associated with histology grading, Dukes stage, serosal invasion and lymph node metastasis (P<0.05), but not with gender, age and the size of tutor (P>0.05). Cofilin-1 was closely related to the prognosis of colonic cancer (P<0.05). Conclusion The detection of Cofilin-1 protein can help judge the invasion, metastasis and prognosis of colonic cancer.