鼻息肉患者外周血Th17细胞的表达及意义

摘要

目的：检测鼻息肉患者外周血中Th17细胞的表达水平，初步探讨其与鼻息肉形成的关系。方法收集46例慢性鼻窦炎伴鼻息肉患者的外周血作为鼻息肉组，另收22例单纯鼻出血或者鼻中隔偏曲患者外周血作为对照组。采用流式细胞术检测两组患者的外周血中的Th17细胞的表达水平。结果鼻息肉组外周血中Th17细胞的表达水平为(4.03±0.69)%，明显高于对照组的(1.35±0.26)%，差异有显著统计学意义(P<0.05)。结论鼻息肉的发生发展可能与高水平表达Th17细胞存在一定关系，具体发病机制有待进一步研究。%Objective To detect the expression of Th17 cells in peripheral blood in nasal polyps, and to ex-plore the role of Th17 cells in pathogenesis of nasal polyposis. Methods The peripheral blood samples were collect-ed from 46 patients of chronic sinusitis with nasal polyp (CRSwNP, the study group) and 22 patients with simple nasal bleeding or nasal septum deviation (the control group). Flow cytometry was used to detect the expression levels of Th17 cells in peripheral blood in the two groups. Results The levels of Th17 cells in the study group was (4.03%± 0.69%), significantly higher than (1.35%± 0.26%) in the control group (P<0.05). Conclusion The pathogenesis of CRSwNP may be involved in the increased expression of Th17 cells, and the detailed mechanisms should be further studied.