目的：应用实时组织弹性成像(RTE)检测健康成人肝纤维化指数(LF index)，分析年龄、性别和体重指数对测值的影响，计算正常参考值范围，为RTE的临床应用提供参考。方法应用RTE检测184例健康体检者的LF index，得到正常参考值范围。根据年龄、性别、体重指数进行分组，采用单因素方差分析、独立样本t检验比较各组间的差异。结果正常成人肝脏LF index均值为(1.67±0.33)，95%可信区间为1.63~1.72。不同年龄组间LF index比较差异均有统计学意义(F=5.981，P=0.001)，40~49岁组、50岁及以上组检测值均大于18~29岁组(P=0.000、0.005)。男性LF index高于女性(t=6.293，P=0.013)。不同BMI组间LF index比较差异均有统计学意义(F=5.695，P=0.004)，肥胖组检测值增大，与偏瘦组和正常组比较差异均有统计学意义(P=0.001、0.005)。结论实时组织弹性成像在健康人群的LF index正常参考值范围为1.63~1.72。年龄、性别和体重指数均对LF index的检测有一定的影响，临床应用中应注意合理解释。%Objective To test the normal value of liver fibrosis index (LF index) in healthy liver with re-al-time tissue elastography (RTE) to analyze its influence on LF index by age, sex and Body Mass Index (BMI). Methods LF indexes of 184 patients with healthy liver were tested by RTE and a normal reference range was calcu-lated. They were divided into different groups according age, sex and BMI. One-way analysis of variance and indepen-dent sample t test were used to analyze the differences among groups. Results The mean value of LF index in healthy adults was (1.67±0.33) and 95%confidence interval was (1.63~1.72). The differences of LF index in different age groups were statistically significant (F=5.981,P=0.001). The LF indexes in 40~49 group and above 50 group were higher than that in 18~29 group (P=0.000, 0.005). The LF indexes of male were higher than that of female (t=6.293, P=0.013). The differences were statistically significant in different BMI groups (F=5.695, P=0.004). The LF index of BMI≥25 kg/m2 was increased and the difference was statistically significant compared with that of BMI<18 kg/m2 and 18 kg/m2≤BMI<25 kg/m2 (P=0.001, 0.005). Conclusion The normal value of LF index in healthy people tested by RTE is 1.63~1.72. Age, Sex and BMI can be impact factors in the test of LF index, and reasonable explanations should be awared of in clinical application.
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