秋水仙碱在心血管疾病中的应用进展

摘要

秋水仙碱是一至今仍在使用的天然、古老的药物，传统上其是治疗痛风的主要药物，同时也是心包炎的二线治疗药物以及家族性地中海热和Behcets病的基础用药。虽然其作用机制并不涉及花生四烯酸途径，而是通过与微管蛋白相结合从而抑制微管聚合，但仍常被归类为抗炎药物。最近的研究表明秋水仙碱可用于治疗多种心血管疾病，并证明了其有效性，本文对有关此方面的研究进展予以综述。%Colchicine, a natural and ancient drug still used today, is traditionally considered as the staple ther-apy for gout and a second-line treatment for pericarditis, as well as a basic part of familial Mediterranean fever and Be-hcet's disease management. It is commonly classified as an anti-inflammatory agent, although its mechanism of action does not involve the arachidonic acid pathway affected. Colchicine inhibits microtubule polymerization by binding to tubulin. Recent studies suggest that colchicine may prove to be useful in a much wider spectrum of cardiovascular dis-eases than previously suspected. In this review we examine what is currently known about the promising role of colchi-cine in cardiovascular medicine.