川崎病冠脉损伤与血清巨噬细胞炎症蛋白-1α水平的相关性

摘要

Objective To investigate the relationship between serum MIP-1αlevel and coronary artery le-sion in Kawasaki disease (KD). Methods The levels of serum MIP-1αfrom 40 KD patients (including 15 patients with coronary artery lesion) and 20 healthy children were detected by enzyme-linked immunosorbent assay. The de-gree of coronary artery dilatation was detected by ultrasonic cardiogram and its association with MIP-1α was ana-lyzed. Results The level of serum MIP-1αin acute KD patients (79.16 ± 11.54) ng/L was significantly higher than that in healthy children (38.16 ± 5.21) ng/L (P<0.05). The level of serum MIP-1αin acute KD patients with coronary artery lesion (89.14±10.52) ng/L was higher than in KD patients with non-coronary artery dilatation (71.15±2.48) ng/L (P<0.05). In addition, the level of serum MIP-1αin KD patients showed positive correlation with the degree of coro-nary artery dilatation (r=0.438, P<0.05). Conclusion The level of serum MIP-1αis significantly higher in KD pa-tients and further higher in KD patients with coronary artery lesion. The serum MIP-1αlevel in KD patients shows a positive correlation with the degree of coronary artery dilatation.%目的：探讨血清巨噬细胞炎症蛋白-1α(MIP-1α)水平与川崎病(KD)冠脉损伤的相关性。方法选取急性期KD患儿40例，其中15例有冠脉损伤，正常对照组20例。采用酶联免疫法（ELISA）检测血清MIP-1α水平，超声心动图检测冠状动脉扩张程度，分析血清MIP-1α水平变化及其与冠状动脉扩张程度的相关性。结果 KD急性期患儿的血清MIP-1α水平为(79.16±11.54) ng/L，高于正常对照组(38.16±5.21) ng/L，差异有统计学意义(P<0.05)；冠脉损伤KD患儿的MIP-1α水平为(89.14±10.52) ng/L，高于无冠脉损伤KD患儿(71.15±2.48) ng/L，差异有统计学意义(P<0.05)。KD患儿血清MIP-1α水平与冠状动脉扩张程度呈正相关(r=0.438，P<0.05)。结论 KD急性期患儿的血清MIP-1α水平明显升高，伴有冠状动脉损伤的KD患儿的水平更高；血清MIP-1α水平与冠状动脉扩张程度呈正相关。