目的：探讨健康人群的年龄与性别对抗核抗体(ANA)表达的影响。方法选取2013年6月至2014年6月在我院行常规体检的健康人群1167例，受试者知情下空腹采血间接免疫荧光法检测ANA表达，以滴度≥1：100为阳性。分析ANA在健康人群中的年龄及性别分布状况。年龄及性别与ANA阳性率的相关性采用Spearman分析。结果1167例健康受试者中ANA阳性者157例，阳性率为13.45%。随着年龄增长，ANA阳性率在健康人群中有明显增大的趋势；而在同一年龄区间，女性的阳性率明显大于男性(P<0.05)。Spearman分析显示，年龄与健康人群ANA阳性率呈正相关性(rs=0.310，P<0.05)；性别与健康人群ANA阳性率呈正相关性(rs=0.608，P<0.01)。结论抗核抗体在健康人群中表达会受年龄和性别因素影响。%Objective To explore the effect of age and gender on distribution of antinuclear antibodies (ANA) in healthy population. Methods A total of 1 167 healthy people who had routine check-up between June 2013 and June 2014 in our hospital were selected. The informed participants were taken fasting blood samples to deter-mine ANA expression by indirect immunofluorescence assay (IFA). Titer≥1:100 was set as positive result. The effect of age and gender on distribution of antinuclear antibodies (ANA) in the healthy population were analyzed. The corre-lations between ANA positive and age or gender were analyzed by Spearman method. Results Among 1 167 partici-pants, 157 showed ANA positive and the positive rate of ANA was 13.45%. There was a significantly increased trend of ANA positive rate with age within the healthy population. The positive rate of female participants was apparently higher than that of male participants in the same age range (P<0.05). Spearman analysis showed that there was a posi-tive correlation between ANA positive rate and age (rs=0.310, P=0.037), and also between ANA positive rate and gen-der (rs=0.608, P<0.001). Conclusion Age and gender would affect the expression of ANA in the healthy population.
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