CIP2A在宫颈癌中的表达及其临床意义

摘要

目的：探讨CIP2A在宫颈癌(Cervical cancer)、宫颈上皮内瘤变(Cervical intraepithelial，CIN)及正常宫颈组织中的表达及其临床意义。方法应用免疫组化S-P法检测50例宫颈鳞状细胞癌、34例CINⅠ、40例CINⅡ、45例CINⅢ及12例正常宫颈组织中CIP2A蛋白的表达。结果 CIP2A蛋白在宫颈癌中的表达明显高于宫颈上皮内瘤变及正常宫颈组织，且与宫颈癌淋巴结转移及临床分期有关，差异均有统计学意义(P<0.05)。结论 CIP2A在宫颈鳞状细胞癌中过表达，且与宫颈癌的恶性临床病理特征密切相关，为将来发展以CIP2A为靶分子的宫颈癌临床诊断和新的治疗策略提供了新的思路。%Objective To explore the expression and clinical significance of CIP2A protein in cervical can-cer, cervical intraepithelial and normal cervical tissue. Methods The expressions of CIP2A in 50 cases of cervical cancer, 34 cases of CINⅠ, 40 cases of CINⅡ, 45 cases of CINⅢand 12 cases of normal tissues were assessed by immunohistochemical S-P method. Results The expression of CIP2A protein in cancer tissues was significantly higher than those in CIN tissues and normal tissues (P<0.05) and closely correlated with TNM stage and metastasis. Conclusion CIP2A is overexpressed in cervical squamous cell cancer and closely correlated with the malignant clinicopathologic feature of cervical cancer. Therefore, CIP2A, as a target molecule, may provide a new thought for the clinical diagnosis and treatment strategy of cervical cancer.