补肾祛毒丸治疗维持性腹膜透析患者营养不良疗效观察

摘要

Objective To observe the clinical effect of nourishing kidney and removing poison pill in patients of continuous ambulatory peritoneal dialysis (CAPD) with malnutrition. Methods Eighty-two CAPD patients with mal-nutrition in our hospital from March 2014 to March 2016 were selected and randomly divided into control group and ob-servation group according to random number table, with 41 patients in each group. Control group was given convention-al symptomatic treatment, and the observation group used nourishing kidney and removing poison pill based on the con-trol group. The two groups of patients were treated for 3 months. After treatment, TCM syndrome, the integral subjective comprehensive nutrition assessment (SGA), and nutritional indexes of transferrin (TRF), plasma albumin (ALB), hemo-globin (Hb), prealbumin (PA) were compared between the two groups. Results After treatment, the total effective rate of observation group was 85.37%(35/41), significantly higher than that in the control group of 63.41%(26/41), with sta-tistically significant difference (P<0.05). After treatment, TCM symptom scores were (12.14 ± 2.89), (17.89 ± 3.13) in the observation group and the control group, significantly decreased compared with those before treatment, and the score in the observation group was significantly lower than that in the control group (P<0.05). After treatment, the SCG score of the observation group were (23.70±4.47), (16.91±4.35), significantly improved compared with before treatment, and the score in observation group was significantly higher than that in the control group (P<0.05). After treatment, Hb, ALB, TRF and PA were (112.43±12.67) g/L, (39.24±4.78) g/L, (2.29±0.44) g/L, (324.56±50.41) mg/L in the observation group and (93.34±10.24) g/L, (31.32±4.14) g/L, (2.08±0.41) g/L, (228.96±44.56) mg/L in the control group, significantly high-er than those before treatment, and the levels in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Nourishing kidney and removing poison pill can improve the clinical symptoms and nutri-tional status of CAPD patients with malnutrition, and improve the quality of life of patients.%目的：观察维持性非卧床腹膜透析(CAPD)营养不良患者服用补肾祛毒丸的临床效果。方法选取2014年3月至2016年3月我院肾内科接受CAPD治疗且出现营养不良患者82例，按数字表法随机将其分为对照组和观察组各41例。对照组予以常规对症支持治疗，观察组在对照组基础上加用补肾祛毒丸治疗，两组患者均治疗3个月。比较两组患者治疗3个月后的中医证候积分、主观综合性营养评分(SGA)及转铁蛋白(TRF)、血浆白蛋白(ALB)、血红蛋白(Hb)及前白蛋白(PA)等营养指标。结果治疗后，观察组患者的总有效率为85.37%(35/41)，明显高于对照组的63.41%(26/41)，差异有统计学意义(P<0.05)；治疗后观察组患者与对照组患者的中医症状积分分别为(12.14±2.89)分、(17.89±3.13)分，均较治疗前显著降低，且观察组显著低于对照组，差异均有统计学意义(P<0.05)；治疗后观察组患者与对照组患者的SCG评分分别为(23.70±4.47)分、(16.91±4.35)分，均较治疗前显著提高，且观察组显著高于对照组，差异均有统计学意义(P<0.05)；治疗后观察组患者的Hb、ALB、TRF、PA依次为(112.43±12.67) g/L、(39.24±4.78) g/L、(2.29±0.44) g/L、(324.56±50.41) mg/L，对照组依次为(93.34±10.24) g/L、(31.32±4.14) g/L、(2.08±0.41) g/L、(228.96±44.56) mg/L，均较治疗前显著提高，且观察组显著高于对照组，差异均有统计学意义(P<0.05)。结论补肾祛毒丸能够改善CAPD营养不良患者的临床症状及营养状况，提高患者的生活质量。