离心造粒法制备裸花紫珠微丸的工艺研究

摘要

Objective To explore the preparation methods of Callicarpa nudiflora micropellets. Methods Mi-cropellets were prepared by centrifugal granulation with powder properties including particle size, roundness, bulk densi-ty, friability and pellets and micropellets yield as the evaluation index. The effect of prescription factors and technologi-cal factors on the pellets were studied. Results Process of the micropellets was as follows:the ratio of extract powder and microcrystalline cellulose was 1:1, with 5%PVP-k30 60%ethanol solution as binder, revolution speed of 200 r/min, spray rate of 5%PVP-k30 60%ethanol solution of 5~25 r/min. Conclusion Under optimal conditions, smooth surface, good roundness micropellets can be obtained by centrifugal granulation method, with pellets yields over 85%.%目的：考察裸花紫珠微丸制备工艺。方法采用离心造粒法，以微丸粉体学性质如粒径、圆整度、堆密度、脆碎度等及微丸收率为指标，考察影响微丸成型的处方因素和工艺因素。结果微丸的制备工艺为：微晶纤维素与药粉(1：1)，以5%PVP-k3060%乙醇溶液为黏合剂，主机转速为200 r/min，以5~25 r/min速度喷5%PVP k-3060%乙醇溶液。结论在优化条件下采用离心造粒法可制得表面光滑，圆整度较好的裸花紫珠微丸，微丸的收率达到85%以上。