双相磷酸钙陶瓷化学组成对其材料性能的影响

摘要

Biphasic calcium phosphates, consisting of hydroxyapatite and beta-tricalcium phosphate, have been extensively applied as bone graft substitutes due to their similarity with the mineral portion of nature bone. They have been proved to have excellent biocompatibility, osteoinductivity and adjustable degradation, which are expected to be-come a good choice for bone graft substitutes. The paper is going to review influences of different chemical composition of biphasic calcium phosphates on the materials' compressive strength, degradation, biological compatibility, osteoinduc-tivity and the research progress of related mechanisms.%双相磷酸钙陶瓷是由一种由羟基磷灰石和β-磷酸三钙按照不同比例混合构成的生物活性陶瓷，其化学组成与骨组织的无机成分十分相近，目前大量研究表明该材料具有优良的生物相容性、骨诱导性、骨传导性及降解速率可调控等特点，因此有望成为理想的骨替代材料。综述双相磷酸钙陶瓷化学组成对其抗压强度、降解性能、细胞生物学行为及骨诱导性的影响及相关机制的研究进展。