Objective To analyze the diagnostic value of procalcitonin (PCT), hypersensitive C-reactive pro-tein (hs-CRP) and white blood cells (WBC) count on neonatal infectious disease, and provide reference for clinical diag-nosis. Methods A total of 62 newborns with infectious diseases, who admitted to the First Affiliated Hospital of Hain-an Medical College from May 2015 to September 2016, were selected as the observation group. Meantime, 65 healthy newborns were selected as the control group. The patients in the observation group were divided into the improvement group and the no-change group. The fasting venous blood was collected in the early morning for all neonates, and the in-dexes of PCT, WBC and hs-CRP were measured. Results Before the treatment, PCT, hs-CRP, WBC count in the obser-vation group were significantly higher than those in the control group (P<0.05). In the observation group, there were 45cases positive in PCT detection, 33 cases positive in hs-CRP detection, and 32 cases positive in WBC count. PCT had the highest detection specificity. The sensitivity of the combined detection was 88.7％, which was significantly higher than that of any single detection (72.6％for PCT, 53.2％for hs-CRP, 51.6％for WBC count) (P<0.05). After the treatment, the indicators of the improvement group were significantly decreased, but the indicators in the no-change group had no significant change. PCT, hs-CRP, WBC count in the improvement group were significantly lower than those in the no-change group (P<0.05). Conclusion In the diagnosis of neonatal infectious diseases, PCT, WBC count, hs-CRP had the higher sensitivity and specificity, which can be used as the clinical diagnostic indicators.%目的 分析血清降钙素原(PCT)、白细胞计数(WBC)、高敏C反应蛋白(hs-CRP)在新生儿感染性疾病中的诊断价值.方法 选取海南医学院第一附属医院2015年5月至2016年9月收治的新生儿感染性疾病患儿62例为观察组,选取同期健康新生儿65例为对照组,观察组患儿依照治疗效果分为改善组和无变化组,所有新生儿均在清晨采集空腹静脉血,测定PCT、WBC、hs-CRP指标.结果 观察组患儿治疗后PCT、hs-CRP、WBC计数均明显高于对照组,差异均有统计学意义(P<0.05);观察组PCT检测阳性45例,hs-CRP检测阳性33例,WBC计数检测阳性32例,PCT检测特异性最高,联合检测敏感性(88.7％)明显高于单独一种检测敏感性(72.6％、53.2％、51.6％),差异均有统计学意义(P<0.05).治疗后,改善组患儿各指标均显著下降,无变化组患儿指标无明显变化,改善组患儿PCT、Hs-CRP、WBC计数明显低于无变化组,差异均有统计学意义(P<0.05).结论 新生儿感染性疾病诊断中,PCT、WBC计数、hs-CRP灵敏性和特异性均较高,均可以作为临床诊断指标.
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