目的 研究冠心病患者血清视黄醇结合蛋白4(RBP-4)水平变化及其与冠状动脉病变严重程度的相关性.方法 选择深圳市龙华区人民医院2015年1月至2016年12月收治的93例冠心病患者为观察组,其中急性心肌梗死(AMI)27例,稳定性心绞痛(SAP)35例,不稳定性心绞痛(UAP)31例;患者均于入院后24 h检测内RBP-4水平,同时行冠状动脉造影检查,计算Gensini评分,采用直线相关性分析RBP-4与Gensini评分的相关性.结果 SAP组患者的RBP-4水平和Gensini评分为(38.46±6.53)mg/L、(37.76±9.28)分,低于UAP组的(48.14±8.29)mg/L、(63.49±11.20)分和AMI组的(62.48±10.67)mg/L、(93.15±18.08)分,而UAP组患者的RBP-4水平和Gensini评分低于AMI组,差异均有统计学意义(P<0.05);RBP-4水平和Gensini评分呈正相关(r=0.682,P=0.000).结论 冠心病患者血清RBP-4水平越高,冠脉狭窄程度越重,提示RBP-4可作为临床冠脉病变诊疗的指标之一.%Objective To study the change of serum retinol binding protein 4 (RBP-4) level in patients with coronary heart disease (CHD) and its correlation with the severity of coronary artery lesions. Methods A total of 93 pa-tients with coronary heart disease, including 27 cases of acute myocardial infarction (AMI), and 35 cases of stable angi-na (SAP), 31 cases of unstable angina (UAP), who admitted to our hospital from January 2015 to December 2016, were selected as the research subjects. The patients were all tested for RBP-4 at 24 h after admission, accompanied by coro-nary angiography, and Gensini score was calculated. The correlation between RBP-4 and Gensini score was analyzed by linear correlation analysis. Results The RBP-4 levels and Gensini score of the SAP group were (38.46 ± 6.53) mg/L, (37.76±9.28), which were significantly lower than (48.14±8.29) mg/L and (63.49±11.20) in the UAP group and (62.48± 10.67) mg/L and (93.15 ± 18.08) in the AMI group The RBP-4 levels and Gensini score in the UAP group were signifi-cantly lower than those in the AMI group (P<0.05). RBP-4 levels were positively correlated with Gensini scores (r=0.682, P=0.000). Conclusion The higher the serum rbp-4 level in patients with coronary heart disease, the greater the degree of coronary stenosis, suggesting that rbp-4 can be used as one of the indicators of the clinical diagnosis and treat-ment of coronary artery disease.
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