去分化脂肪细胞多向分化潜能与应用

摘要

Dedifferentiated fat cells (DFAT cells) derived from matured adipocytes, similar to stem cells, have multilineage differentiation potential. DFAT cells can be collected by ceiling culture in vitro. Under appropriate culture conditions for inducing differentiation, DFAT cells can transdifferentiate into adipocytes, osteoblasts, chondrocytes, en-dothelial cells, muscle cells, nerve cells and so on. Therefore, DFAT cells are considered as a potential resource for tis-sue engineering and stem cell therapy, which are widely used in various diseases and tissue damage repair studies.%去分化脂肪细胞(DFAT cells)来源于成熟脂肪细胞,且具有多向分化潜能,其特征类似于干细胞的一种细胞.在体外可通过天花板培养法提取出DFAT细胞,经过诱导后,DFAT细胞可向脂肪细胞、骨细胞、软骨细胞、内皮细胞、肌细胞、神经细胞等分化.因此,DFAT细胞是一种在组织工程和干细胞治疗中很好的潜在资源,从而广泛应用于多种疾病及组织损伤修复的研究当中.