不同亚型干扰素雾化吸入与常规抗病毒治疗疱疹性咽峡炎临床疗效对比研究

摘要

目的 探讨两种不同亚型干扰素雾化与常规抗病毒治疗疱疹性咽峡炎的临床疗效.方法 选择2015年6月至2016年10月期间我院儿科诊治的120例疱疹性咽峡炎患儿为观察组,选择同期健康体检儿童100例为对照组,比较两组患者心肌酶谱水平;将观察组患儿根据随机数字表法随机分为A、B、C三组,每组40例,分别予雾化吸入α-1b、α-2b干扰素及静滴利巴韦林治疗,比较三组患儿的临床疗效及不良反应.结果 观察组患儿的乳酸脱氢酶(LDH)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)水平明显高于对照组,差异均有统计学意义(P<0.05);A组和B组患儿的治疗有效率分别为97.5%和95.0%,明显高于C组的82.5%,差异均有统计学意义(P<0.05),但A组和B组的治疗有效率比较差异无统计学意义(P>0.05);A组和B组患儿的退热时间、疱疹消失时间、平均住院天数均明显短于C组,差异均有统计学意义(P<0.05),A组和B组间比较差异无统计学意义(P>0.05);三组患儿的不良反应发生率比较差异无统计学意义(P>0.05).结论 干扰素雾化吸入治疗疱疹性咽峡炎的临床疗效明显优于利巴韦林,但不同亚型干扰素疗效相当.%Objective To investigate the clinical efficacy of atomization inhalation of two subtypes of interfer-on and conventional antiviral therapy in the treatment of herpangina. Methods From June 2015 to October 2016, 120 patients of herpangina in Department of Pediatrics of our hospital were included into the observation group, and 100 healthy children were included into the control group. The myocardial enzyme levels were compared. According to random number table, the observation group were further divided into A, B, C three subgroups (n=40 each), which were treated byα-1b,α-2b inhalation and intravenous injection of ribavirin, respectively. The clinical efficacy and adverse re-actions of three subgroups were compared. Results The lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-isoenzyme MB (CK-MB), aspertate Aminotransferase (AST) in the observation group were significantly higher than those in the control group (P<0.05). The effective rate was 97.5% in group A and 95.0% in group B, significantly higher than 82.5% in group C (P<0.05), but there was no significant difference between group A and B (P>0.05). The fe-ver time, herpes disappear time, the average length of hospital stay in group A, group B were significantly shorter than those in group C (P<0.05), but there was no significant difference between group A and B (P>0.05). There was no signifi-cant difference in adverse reaction rate between the three subgroups (P>0.05). Conclusion Interferon atomization inha-lation is better than intravenous injection of ribavirin in the treatment of herpangina, but the two subtypes of interferon have equivalent curative effect.