急性缺血性脑卒中患者T细胞亚群与NIHSS评分相关性研究

摘要

目的 探讨急性缺血性脑卒中患者的T细胞亚群与NIHSS评分的相关性.方法 选取2017年1~10月高州市人民医院神经内科收治的160例确诊急性缺血性脑卒中患者为实验组,所有脑卒中患者入院当天按神经功能情况进行NIHSS评分,同时选取相对应的中老年健康体检者80例为对照组,对所有研究对象进行流式T细胞亚群分析,比较CD3+、CD4+、CD8+和CD4+/CD8+水平在两组中的差异,分析各亚群与NIHSS评分的相关性.结果 实验组患者的CD3+、CD4+和CD4+/CD8+均明显高于对照组,而CD8+明显低于对照组,差异均有统计学意义(P<0.05);实验组患者的CD3+、CD4+和CD4+/CD8+与NIHSS评分呈显著正相关(r=0.295,0.498, 0.887,P<0.05),而CD8+与NIHSS评分呈显著负相关(r=-0.352,P<0.05).结论 T细胞亚群与急性缺血性脑卒中NIHSS评分相关,与其疾病的发生和发展相关.%Objective To investigate the correlation between NIHSS score and T cell subsets in patients with acute ischemic stroke (AIS). Methods A total of 160 patients with AIS admitted to Department of Neurology, Gaozhou People's Hospital from January 2017 to October 2017 were selected as the experimental group. All stroke patients were evaluated for the National Institute of Health Stroke Scale (NIHSS) score on admission day according to the nerve func-tion. At the same time, 80 healthy middle and old age persons were selected as the control group, and all subjects under-went flow cytometry. The differences of CD3+, CD4+, CD8+and CD4+/CD8+levels between the two groups were com-pare, and the correlation between the subgroups and the NIHSS score were analyzed. Results The levels of CD3+, CD4+and CD4+/CD8+in experimental group were significantly higher than those in control group, but CD8+was signifi-cantly lower than that of the control group (P<0.05). The CD3+, CD4+and CD4+/CD8+of the experimental group were positively correlated with the NIHSS score (r=0.295, r=0.498, r=0.887, P<0.05), but the CD8+in the experimental group were negatively correlated with the NIHSS score (r=-0.352, P<0.05). Conclusion T cell subsets were associat-ed with the NIHSS score of AIS, and it is related to the occurrence and development of the disease.