服用奥氮平、利培酮精神分裂症患者的心电图分析

摘要

Objective Taking olanzapine, risperidone schizophrenia ECG changes. Methods Randomly taking olanzapine 160 cases, risperidone 60 cases of schizophrenia ECG analysis. Methods randomly taking olanzapine 160 cases, risperidone 60 cases of schizophrenia ECG analysis. Results Olanzapine group electrocardiogram was normal 65 cases (40.63%), abnormal electrocardiogram 95 cases (59.37%). Risperidone group electrocardiogram was normal 22 cases (36.67%) abnormal electrocardiogram 38 cases (63.33%), two drugs can cause ECG changes. Major sinus tachycardia, bradycardia, arrhythmia, ST-T changes, T wave abnormalities, QT interval prolongation, short PR interval, U wave changes. No signiifcant difference between the two (P>0.05). With the increase in treatment time and dose rate of abnormal ECG two drugs also increased. Conclusion Olanzapine and risperidone affect electrocardiographic changes, particularly an increase in drug and long-term use of high-dose patients should review the ECG.%目的：了解服用奥氮平、利培酮治疗精神分裂症患者心电图变化情况。方法随机对服用奥氮平160例，利培酮60例精神分裂症患者心电图进行分析。结果奥氮平组心电图表现正常65例（40.63％），心电图异常95例（59.37％）。利培酮组心电图表现正常22例（36.67％）心电图异常38例（63.33％），两药均可引起心电图改变。主要窦性心动过速，过缓，心律不齐，ST-T改变，T波异常，Q-T间期延长，短P-R间期，U波改变。二者无明显差异（P＞0.05）。随着用药时间和剂量的增加两药的心电图异常率亦增加。结论奥氮平与利培酮都会影响心电图改变，特别在药物增加和大剂量长期应用患者应复查心电图。