抗溃疡性结肠炎药物4-氨基水杨酸衍生物对IL-13的作用

摘要

Objective To investigate the effects of 4-aminosalicylic acid (4-ASA) derivative on interleukin (IL)-13 in RAW264.7 cell induced by lipopolysaccharide(LPS).Methods After the intervention was conducted on normal control group, model group,Sulfasalazine positive control group and 4-aminosalicylic acid derivative with low,medium and high dose group for 24 hours,the expressions of IL-13 were identified with enzyme-linked immunosorbent assay(ELISA). Results Under the doses of 10,40,160 µg.ml-1, the concentration of IL-13 was promoted by 4-ASA derivative. Conclusion 4-ASA derivative promoted the concentration of IL-13.%目的观察4-氨基水杨酸衍生物对脂多糖诱导RAW264.7细胞产生IL-13的影响。方法设正常对照组、模型组（脂多糖组）、柳氮磺胺吡啶阳性对照组、4-氨基水杨酸衍生物低、中、高剂量组，给药24h后，ELISA检测上清中IL-13的含量。结果4-氨基水杨酸衍生物在10、40、160µg/mL时均能促进IL-13的表达。结论4-氨基水杨酸衍生物促进抑炎因子IL-13的表达。