BNP在急性呼吸困难患者中的临床价值分析

摘要

目的探讨脑钠肽(BNP)在急性呼吸困难患者诊治中的临床意义.方法将在我院住院的116例急性呼吸困难患者分为心源性呼吸困难组及非心源性呼吸困难组,测定每位患者的血浆BNP,同时每位患者均给予超声心动图检查测定左室射血分数(LVEF).对两组及心源性呼吸困难组治疗前后血浆BNP含量进行比较.结果心源性呼吸困难组患者的血浆BNP浓度明显高于非心源性呼吸困难组(P<0.01).心源性呼吸困难患者中疗效良好组(NYHA级别改善≥Ⅱ级者),BNP水平显着下降(P<0.01).结论血浆BNP测定对心源性呼吸困难与非心源性呼吸困难的鉴别有显著意义,在以心源性因素导致呼吸困难患者中,BNP含量变化与患者病情转归密切相关.%Objective To study the clinical significance of the brain natriuretic peptide (BNP) in patients presenting with acute dyspnea. Methods 116 patients presenting with acute dyspnea were divided into cardiac dyspnea group and non-cardiac dyspnea group, The BNP level were obtained and left ventricular ejection fraction (LVEF) of all patients were measured by echocardiogram. The variation of BNP level of the two groups and patients suffered from cardiac failure around the therapy were researched. Results The BNP level of the patients in cardiac dyspnea group was higher than that of those in non-cardiac dyspnea group (P<0.01). The BNP level of the patients with well-prognosis group (NYHA improved≥Ⅱ) decreased obviously by therapy(P<0.01). Conclusion The BNP is very important in distinguishing the reason of dyspnea caused by cardiac or non-cardiac dyspnea. The variation of BNP level relates with the prognosis of ill in patients with cardiac dyspnea.