ObjectiveTo investigate angiotensinⅡ receptor antagonist for type 2 diabetes lower limb arteriosclerosis related factors.MethodsFrom August 2011 to July 2013 in type 2 diabetes lower limb arteriosclerosis occlusion and 76 cases of hypertension patients in this study, routine hypoglycemic lipid adjusting treatment, on admission examination indexes of blood glucose, blood pressure, blood fat, nitric oxide, experimental group 38 cases given oral antihypertensive treatment with chlorine sand, adjust dosage according to each index levels. 38 cases were treated except the AT-II antagonists of blood pressure medication. Observe patients treatment 2 weeks, 4 weeks, 12 weeks when the blood lipid level and the change of nitric oxide.ResultsCompared with on admission, we found that 2 weeks, 4 weeks, 12 weeks after treatment in patients with TC, TG, LDL - C index level declined obviously, nitric oxide, HDL-C rise obviously, after statistical analysis that the significant difference(P<0.05). The indicators and the control group with significant difference(P>0.05).ConclusionIn type 2 diabetes mellitus in the clinical treatment of lower limb arteriosclerosis by angiotensinⅡ receptor antagonist treatment can improve blood lipid, hardening of the arteries relevant factors such as nitric oxide, stable atherosclerotic plaques, is positive for the prognosis of patients with clinical signiifcance.%目的：探讨血管紧张素Ⅱ受体拮抗剂对2型糖尿病下肢动脉硬化相关因素的影响。方法将我院2011年8月至2013年7月收治的2型糖尿病下肢动脉硬化闭塞并有高血压患者76例纳入本研究，常规降糖调脂治疗，入院时检查血糖、血压、血脂、一氧化氮等指标，试验组38例给予氯沙坦口服降压治疗，根据各项指标检测水平调整用药剂量。对照组38例给予除AT-II拮抗剂外的降压药。观察患者治疗2、4、12周时血脂水平和一氧化氮的变化。结果与入院时对比，我们发现治疗后2周、4周、12周时患者TC、TG、LDL-C等指标水平明显下降，一氧化氮、HDL-C明显上升，差异经统计学分析后认为有意义（P＜0.05）。其各项指标跟对照组有显著差异（P＞0.05）。结论在2型糖尿病下肢动脉硬化的临床治疗中采用血管紧张素Ⅱ受体拮抗剂治疗可改善血脂、一氧化氮等动脉硬化相关因素、稳定粥样硬化斑块，对患者的预后具有积极的临床意义。
展开▼
