MMP-7表达在早期胃癌淋巴结转移中的预测地位

摘要

Objective Matrix metalloproteinases have been shown to be involved in the pathogenesis of tumor progression and metastasis in gastric carcinoma.In this study,we investigated the association between MMPs expressions and lymph node metastasis in early gastric carcinoma. Methods Thirty-four LN positive and 80 LN negative pT1 tumors were immunohistochemically analyzed for MMP-2,MMP-7,and MMP-9 expression.The relation of MMPs expressions to LN metastasis was analyzed in the multivariete model. Results Immunohistochemistry showed significantly higher MMP-7 expression (P<0.05) in LN positive tumors,whereas MMP-9 and MMP-2 in LN positive vs.57.5%in LN negative expression did not reach statistical significance. Multivariete analysis revealed that MMP-7 expression is an independent predictor of LN metastasis in EGCs, along with lymphatic invasion by tumor cells(P<0.001) . Conclusion Our study shows that MMP-7 expression is significantly associated with LN metastasis in EGC.MMP-7 expression can be used to predict LN status in EGCs in addition to other pathological parameters.%目的：基质金属蛋白酶家族（MMPs）在胃癌的发病机制和转移机制中发挥着重要作用，本实验研究早期胃癌的淋巴结转移和MMPs表达之间的相互关系，希望能为临床预测早期胃癌是否存在淋巴结转移提供一些帮助。方法应用免疫组织化学方法，检测34例淋巴结阳性与80例淋巴结阴性的pT1早期胃癌组织中MMP-2、MMP-7、MMP-9的表达情况，并用Multivariete统计学方法进行MMPs表达和淋巴结转移之间的相关性分析。结果淋巴结转移阳性的早期胃癌组织中MMP-7阳性表达率为82.3%，而淋巴结转移阴性的早期胃癌组织MMP-7阳性表达率为54.4%，二者相比统计学有显著差异（P＜0.05）。反而，MMP-9和MMP-2在早期胃癌组织中的阳性表达率与淋巴结转移情况间均无统计学意义。Multivariete分析表明，MMP-7表达是预测早期胃癌是否存在淋巴结转移的重要因子（P＜0.05），同时肿瘤细胞的淋巴管浸润也是预测早期胃癌是否存在淋巴结转移不可缺少的因子（P＜0.001）。结论 MMP-7表达与早期胃癌淋巴结转移之间有明显的相关性，可作为早期胃癌是否存在淋巴结转移的重要预测指标。