目的：探讨联合检测糖化血红蛋白（HbA1c）、尿微量白蛋白（UmA1c）、胱抑素C（CysC）和同型半胱氨酸（Hcy）在预测、诊断和治疗糖尿病早期肾病的关系。方法检测108例单纯糖尿病组和52例糖尿病早期肾病的HbA1c、CysC、Hcy、UmA1c水平变化；以100例健康体检者为对照组。结果糖尿病早期肾病组的几项检测水平均高于单纯糖尿病组和健康对照组，差异有统计学意义（P＜0.05）；在单纯糖尿病和健康对照组比较中CysC、HbA1c水平差异有统计学意义（P＜0.05）；而Hcy和UmA1c差异无统计学意义（P＞0.05）。结论联合检测HbA1c、CysC、Hcy、UmA1c可提高糖尿病肾病的早期诊断效率，并在控制血糖和病程进展中有监测作用，对于延缓甚至逆转糖尿病早期肾病具有积极意义。%Objective To explore the combined detection of glycosylated hemoglobin (HbA1c), urine trace albumin urinary inhibition (UmA1c), Cystatin-C (CysC) and homocysteine (Hcy) in the prediction, diagnosis and treatment of early diabetic nephropathy.Methods 108 cases of simple diabetes group and 52 cases of early diabetic nephropathy HbA1c, CysC, Hcy, UmA1c level changes; in 100 cases of healthy physical examination for the control group.Results Several levels of early diabetic nephropathy group were higher than simple diabetes group and healthy controls, the difference was statistically signiifcant (P<0.05); CysC in pure diabetes compared with healthy controls, HbA1c level difference was statistically signiifcant (P<0.05);and Hcy and UmA1c difference has no statistical signiifcance (P>0.05).Conclusion The combined detection of HbA1c, CysC, Hcy, UmA1c can improve the efifciency of the early diagnosis of diabetic nephropathy, and in the control of blood sugar and progression monitoring function, to slow or reverse diabetes early kidney disease has positive signiifcance.
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