糖尿病合并肺部感染血CD4+CD25+调节性T细胞的变化及意义

摘要

To investigate the effect of CD4 + CD25 + regulatory T cells in the immune mechanism in diabetes mellitus patients complicated with pulmonary infection. Methods The CD4 + CD25 + , CD4 + of twenty patients with diabetes mellitus complicated with pulmonary infection before treatment( DM-P group )and post curing( DM group ),20 subjects of pulmonary infection( pulmonary infection group )and 30 subjects of normal( normal control group )were measured by flow cytometry, and their CD4 + CD25 +/CD4 + ratios were calculated. Results The CD4 + CD25 + regulatory T cells counts and the ratios of CD4 + CD25 +/CD4 + in DM-P group and pulmonary infection group were higher than that in normal control group( P < 0.01 ), and the ratios of CD4 + CD25 +/CD4 + in DM-P group and DM group were lower than that in pulmonry infection group( P ＜ 0.05 ). Conclusion The decrease of CD4 + CD25 + count may correlated with the immune deficiency ,anti-inflammatory disturbance and refractory infection of diabetes mellitus patients complicated with pulmonary infection.%目的 探讨CD4+CD25+调节性T细胞在糖尿病合并肺部感染患者免疫机制中的作用.方法 20例糖尿病合并肺部感染患者,于治疗前(DM-P组)及治愈后(DM组)分别用流式细胞仪检测血CD4+、CD4+CD25+,计算CD4+CD25+/CD4+比值,并与20例肺部感染患者(肺部感染组)、30例健康体检者(健康对照组)比较.结果 DM-P组及肺部感染组CD4+CD25+调节性T细胞数量及比值均显著高于健康对照组(P＜0.01),DM-P组及DM组CD4+CD25+调节性T细胞数量及比值显著少于肺部感染组(P＜0.05).结论 CD4+CD25+调节性T细胞比例减少可能与糖尿病合并肺部感染者存在免疫缺陷、致炎及抗炎失衡、感染难治愈有关.