代谢综合征患者血清Apelin水平与血糖的关系

摘要

Objective To investigate the retationship betvveen serum apetin tevet and ptasma gtucose in patients vvith metabotic syndrome( MS ). Methods Sixty nine MS patients inctuding 35 cases of type 2 diabetes mettitus( MS I group ) and 34 cases of impaired gtucose regutation( MS II group ), and 63 cases of normat gtucose regutation inctuding 33 cases of overweight, or obesity( overweight/obesity group ) and 30 heaUhy controts( MC group ) were enrotted in the study. ELISA assay was used to detect serum apetin tevets in four groups. Fasting ptasma gtucose( FPG ) and insutin were determined, and the steady-state modet was apptied to evatuate 110MA insutin resistance( 110MA-1R ). Resutts The serum apetin tevet of MS I group[ ( 475. 8 ±37. 3 )ng/L] was higher than that of MS E group[ ( 451. 5 ±54.7 )ng/L], and overweight/obesity group significantty[ ( 430. 3 ±52. 1 )ng/L,P ＜0. 01 ];The serum apetin tevet of each group above was higher than that of MC group significantty. Conctusion Diabetes/impaired gtucose regutation teads to the increase of serum apetin tevet,which migtit be caused by the increased insutin resistance.%目的 探讨代谢综合征(MS)患者血清Apelin水平与血糖的关系.方法 MS 69例和糖调节正常者63例;前者包括2型糖尿病(MS Ⅰ组)35例和糖调节受损(MS Ⅱ组)34例,后者包括超重/肥胖33例(超重/肥胖组)和健康对照30例(健康对照组).采用酶联免疫吸附法测定各组血清Apelin含量及空腹血糖、胰岛素水平,以稳态模型评价胰岛素抵抗指数(HOMA-IR).结果 MS Ⅰ组血清Apelin水平明显高于MS Ⅱ组及超重/肥胖组[(475.8±37.3)ng/L vs (451.5±54.7)ng/L vs (430.3±52.1)ng/L](P＜0.01),且均高于健康对照组.结论 糖尿病/糖调节受损可以引起血清Apelin水平升高,其可能是由于胰岛素抵抗加重所致.