肺癌患者血浆纤维蛋白原、D-二聚体及抗凝血酶Ⅲ水平的变化及临床意义

摘要

目的：观察肺癌患者血浆纤维蛋白原（ FIB ）、D-二聚体及抗凝血酶Ⅲ（ AT-Ⅲ）水平变化并探讨其临床意义。方法肺癌患者73例（观察组），健康志愿者60例（对照组），检测两组血浆FIB、D-二聚体及AT-Ⅲ水平。结果观察组血浆FIB、D-二聚体水平显著高于对照组，而AT-Ⅲ水平显著低于对照组（ P均＜0．05）；Ⅲ、Ⅳ期患者血浆FIB、D-二聚体水平高于Ⅰ、Ⅱ期（P＜0．05），而Ⅲ、Ⅳ期患者AT-Ⅲ水平低于Ⅰ、Ⅱ期（P＜0．05）。结论检测FIB、D-二聚体以及AT-Ⅲ的水平可作为肺癌进展的辅助诊断指标。%Objective To observe the changes of plasma fibrinogen ( FIB ) , D-dimer and antithrombin Ⅲ( AT-Ⅲ) in patients with lung cancer ,and to explore their clinical significance .Methods Seventy-three cases of lung cancer(observation group) and 60 healthy volunteers(control group) were enrolled in the study,the plasma FIB,D-dimer and AT-Ⅲlevels were detected in two groups .Results The FIB,D-dimer levels of observation group were significantly higher than those of control group,while the AT-Ⅲlevel was significantly lower than that of control group (all P<0.05). The plasma FIB,D-dimer levels of patients in phases Ⅲ,Ⅳwere higher than those of patients in phasesⅠ,Ⅱ(P<0.05), while the AT-Ⅲlevel of patients in phases Ⅲ,Ⅳwas lower than that of patients in phasesⅠ,Ⅱ(P<0.05).Conclusion The detection of FIB ,D-dimer and AT-Ⅲlevels can be used as the auxiliary indexes for the diagnosis of lung cancer progression .