维生素E联合维生素C辅助治疗新生儿缺氧缺血性脑病的效果观察

摘要

目的：观察维生素E联合维生素C辅助治疗新生儿缺氧缺血性脑病（ HIE）的临床效果。方法 HIE患儿90例，按随机数字表法分为治疗组48例，对照组42例。两组均给予常规治疗，治疗组在常规治疗的基础上联合予口服维生素E及静脉滴注维生素C，均治疗2周。观察两组治疗前后血清超氧化物歧化酶（ SOD）、谷胱甘肽过氧化物酶（ GSH-Px）、丙二醛（MDA）水平及临床疗效。结果治疗组治疗后SOD、GSH-Px水平明显升高，而MDA水平明显下降（P＜0．05），而对照组治疗前后上述指标无变化（P＞0．05）。治疗组的总有效率为75．0％，对照组的总有效率为61．9％，治疗组疗效优于对照组（P＜0．05）。结论维生素E联合维生素C辅助治疗HIE获得较好的临床效果，其治疗作用可能通过抗氧化途径实现。%Objective To observe the clinical efficacy of adjuvant therapy of vitamin E and vitamin C on newborn with hypoxic-ischemic encephalopathy(HIE).Methods Ninety newborns with HIE were divided into treatment group(n=48) and control group(n=42) by random number table .The two groups were given conventional therapy .Treatment group were administrated vitamin E orally and vitamin C intravenously based on the conventional therapy .The therapeutical duration was two weeks in both groups .Before and after treatment ,the serum levels of superoxide dismutase ( SOD) ,glutathione peroxidase ( GSH-Px) and malondiadehyde ( MDA) as well as the clinical efficacy were observed in the two groups .Results The serum levels of SOD and GSH-Px increased significantly while the serum level of MDA decreased significantly in the treatment group after treatment (P<0.05),but no changes in the levels of SOD,GSH-Px and MDA were observed in the control group after treatment(P>0.05).The total effective rates of treatment group and control group were 75.0% and 61.9%,respectively,and the efficacy of treatment group was superior to that of control group ( P<0.05).Conclusion The adjuvant therapy of vitamin E and vitamin C obtains a good efficacy on HIE .And it might take effect by the way of antioxidantion .