胱硫醚β-合成酶T833C基因多态性与原发性高血压关系的Meta分析

摘要

Objective To evaluate the relationship between cystathionine beta-synthase(CBS) T833C polymorphism and essential hypertension(EH).Methods Wangfang Data,CNKI,VIP,Embase Database and PubMed were searched for the case-control study on the relationship between Chinese CBS T833C polymorphism and EH.Two reviewer independently evaluated the quality of the included studies and extracted the effective data.RevMan 5.2 software was applied to the Meta-analysis.Results Five case-control studies on the relationship between CBS T833C polymorphisms and EH were included,involving 1747 patients(case group) and 1698 controls.The result of Meta-analysis revealed that CBS T833C mutation increased the susceptibility of EH in Chinese population(OR 1.90,95%confidence interval 1.02-3.53, P<0.05).Conclusion CBS T833C mutation positively correlates with EH in Chinese population.%目的：探讨胱硫醚β-合成酶（CBS）T833C基因多态性与原发性高血压（EH）的相关性。方法计算机检索万方数据知识服务平台、中国知网、维普资讯、Embase数据库及 PubMed，收集有关中国人CBS T833C基因多态性与EH的病例－对照研究。由两名研究员独立评价纳入文献的质量，提取有效数据，采用RevMan 5．2软件进行Meta分析。结果共纳入5个研究CBS T833C基因多态性与EH关系的病例－对照研究，其中病例组1747例，对照组1698例。 Meta分析结果显示，CBS基因T833位点C突变与EH发病风险正相关（OR＝1．90，95％CI：1．02～3．53，P＜0．05）。结论 CBS 基因T833位点C突变与EH发病风险正相关。