血小板分布宽度与慢性完全闭塞性冠状动脉病变的关系

摘要

Objective To explore the platelet distribution width (PDW) with chronic total occlusion of coronary artery (CTO). Methods A total of 255 patients undergoing coronary angiography were enrolled and were divided into normal coronary artery group , non-CTO coronary heart disease group and CTO group ,with 85 cases in each group .The clinical data and blood biochemical indices were compared among three groups .The risk factors for incidence of CTO in patients with coronary heart disease were analyzed using multivariate logistic regression analysis .The sensitivity and specificity of PDW for predicting CTO were assessed using receiver operating characteristic (ROC) curve.Results The level of PDW in CTO group was significantly higher than those in the other two groups (P<0.05).The result of multivariate logistic regression analysis showed that PDW ,WBC and Gensini score were the risk factors for incidence of CTO in patients with coronary heart disease (P<0.05).The result of ROC curve showed that the sensitivity and specificity were 73.0% and 57.0%, respectively,when the cut-off value of PDW was 12.35.PDW positively correlated with the severity of coronary artery lesion in CTO group (r=0.946,P<0.05).Conclusion PDW correlates with CTO.The former can independently predict the CTO and evaluate the severity of coronary artery lesion,and obtains a better sensitivity .%目的：探讨血小板分布宽度（PDW）与慢性完全闭塞性冠状动脉病变（CTO）的关系。方法选取行冠状动脉造影的255例患者，将其分为冠状动脉正常组、冠心病非CTO组和CTO组，每组85例。比较3组患者的临床资料及血生化指标，采用多元logsitic回归分析冠心病患者发生CTO的危险因素，采用受试者工作特征（ ROC）曲线分析PDW预测CTO的敏感性及特异性。结果 CTO 组 PDW 水平明显高于其余两组（ P ＜0．05）。多因素 logistic 回归分析结果显示 PDW、WBC、Gensini积分是冠心病患者发生CTO的危险因素（P＜0．05）。 ROC曲线结果显示，PDW截点值为12．35时，PDW预测CTO的敏感性和特异性分别为73．0％和57．0％。 PDW与CTO组冠状动脉病变严重程度呈正相关（r＝0．946，P＜0．05）。结论 PDW与CTO有关，前者可独立预测CTO的发生及评估冠状动脉狭窄程度，并且具有较好的敏感性。