蛋白磷酸酶2A的癌性抑制因子与c-Myc在鼻咽癌组织中的表达及其相关性研究

摘要

目的 探讨鼻咽癌组织中蛋白磷酸酶2A的癌性抑制因子(CIP2A)与c-Myc表达及其临床意义.方法 应用免疫组织化学染色技术检测68例鼻咽癌组织(鼻咽癌组)和20例鼻咽黏膜慢性炎组织(对照组)CIP2A、c-Myc蛋白的表达,分析CIP2A、c-Myc与鼻咽癌临床病理特征的关系.结果 鼻咽癌组的CIP2A和c-Myc阳性表达率分别为54.4％(37/68)、66.2％ (45/68),均高于对照组的15.0％ (3/20)、25.0％ (5/20)(P＜0.05).CIP2A和c-Myc蛋白阳性表达与鼻咽癌患者性别、年龄、临床分期、肿瘤大小以及有无淋巴结转移无关(P＞0.05).鼻咽癌组织中CIP2A与c-Myc蛋白表达呈正相关(P＜0.05).结论 CIP2A和c-Myc在鼻咽癌组织中表达均升高,可能共同参与鼻咽癌的发生发展过程.%Objective To investigate the expressions and clinical significance of cancerous inhibitor of protein phosphatase 2A (CIP2A) and c-Myc in nasopharyngeal carcinoma tissues.Methods Immunohistochemistry staining was used to detect the CIP2A and c-Myc expressions in 68 samples of nasopharyngeal carcinoma tissues(nasopharyngeal carcinoma group) and 20 samples of chronic inflammatory tissues of nasopharyngeal mucosa(control group).The relationship of CIP2A and c-Myc with clinicopathological features of nasopharyngeal carcinoma was analyzed.Results The positive expression rates of CIP2A and c-Myc in the nasopharyngeal carcinoma group were 54.4％ (37/68) and 66.2 ％ (45/68) respectively,were higher than those in the control group [15.0％ (3/20),25.0％ (5/20) respectively] (P ＜ 0.05).The positive protein expressions of CIP2A and c-Myc in the nasopharyngeal carcinoma tissues did not correlate with gender,age,clinical stage,tumor size or lymph node metastasis (P ＞ 0.05).The protein expression of CIP2A positively correlated with the protein expression of c-Myc in nasopharyngeal carcinoma (P ＜ 0.05).Conclusion Up-regulated expressions of both CIP2A and c-Myc can be observed nasopharyngeal carcinoma tissues,and both of them might involve in the occurrence and development of nasopharyngeal carcinoma.