Objective To explore the efficacy of Dahuang Hongteng Anti-Inflammatory Recipe and its effects on serum procalcitonin(PCT) and soluble intercellular adhesion molecule-1(sICAM-1) in patients with severe acute pancreatitis(SAP). Methods Seventy-six patients with SAP were randomly divided into control group and study group according to the random number table method, with 38 cases in each group. Both groups were given somatostatin on the basis of conventional treatment. The study group received the adjuvant therapy with Dahuang Hongteng Anti-Inflammatory Recipe based on the therapy performed in the control group. Serum PCT, sICAM-1,serum amylase and WBC count were compared between the two groups before and after treatment,and the duration for serum amylase and WBC count recovery,duration for bowel sounds recovery,durations for abdominal pain and abdominal distension improvement, and first defecation time after treatment were compared as well. Results After treatment,the levels of serum PCT and sICAM-1 decreased significantly in the two groups compared to those before treatment,and the levels in the study group were lower than those in the control group(all P<0. 05). After treatment,the serum level of amylase and WBC count decreased in both groups compared to those before treatment,and the WBC count in the study group was lower than that in the control group(all P<0. 05). The study group obtained less durations of serum amylase and WBC count recovery,less duration for bowel sounds recovery,less durations for abdominal pain and abdominal distension improvement and early first defecation time after treatment compared to the control group(all P<0. 05). Conclusion The adjuvant therapy with Dahuang Hongteng Anti-Inflammatory Recipe can effectively reduce the levels of inflammatory factors,improve the gastrointestinal motility,alleviate clinical symptoms and promote the patients′recovery earlier among SAP patients.%目的 探讨大黄红藤消炎方对重症急性胰腺炎(SAP)患者的疗效及血清降钙素原(PCT)、血清可溶性细胞间黏附分子-1(sICAM-1)的影响.方法 选取76名SAP患者分为对照组和研究组,每组38例.两组均在常规治疗基础上给予生长抑素治疗,研究组在对照组的治疗方案基础上加用大黄红藤消炎方辅助治疗.比较治疗前后两组血清PCT、sICAM-1、血淀粉酶及WBC计数,血淀粉酶及WBC计数恢复正常所需时间,以及肠鸣音恢复时间、腹痛及腹胀改善所需时间以及首次排便时间.结果 治疗后两组患者血清PCT、sICAM-1水平均较治疗前水平下降,且研究组低于对照组(均P<0.05).治疗后两组患者血淀粉酶、WBC计数水平均较治疗前下降,且研究组WBC计数低于对照组(均P<0.05).研究组血淀粉酶、WBC计数恢复正常所需时间、肠鸣音恢复、腹痛及腹胀缓解所需时间、初次排便时间均短于对照组(均P<0.05).结论 使用大黄红藤消炎方辅助治疗SAP能够有效降低炎症因子水平,促进胃肠动力,缓解患者临床症状,促进其早日康复.
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