中药养胃散对大鼠胃肠黏膜中前列腺素及生长抑素含量的影响

摘要

Objective To explore the mechanism of Yangwie San(YS) therapy by molecular biology. Methods The levels of prostaglandin (PG) and somatostalin(SS) in gastrointestinal mucosa of SD rats were investigated after ten- day gastric infusion of YS in a model of gastric mucosa damage induced by indomethacin. Results YS can markedly increased the levels of PG(249.42 pg/ml) and SS (2.020 pg/ml) in damaged gastrointestinal mucosa induced by indomethacin, significantly higher than those of the control group( P < 0.01). Condusion YS can increase the secretion of PG and SS in gastrointestinal mucosa, one of mechanism to stregthen gastric mucosa protective barrier.%目的从分子生物学方面探讨养胃散的治疗机制，测定用药后胃肠黏膜中前列腺素(PG)、生长抑素(SS)的变化规律。方法 SD大白鼠为实验动物，以消炎痛损伤胃黏膜后，再给予中药养胃散10 d，用放射免疫法测定胃、肠黏膜中的PG及SS的变化。结果养胃散能明显增加消炎痛损伤后胃肠黏膜中的PG(249.42 pg/ml)及SS(2.020 pg/ml)的含量，与消炎痛组相比差异有显著性(P<0.01)。结论中药养胃散能增加胃肠黏膜内PG及SS的分泌，是其增强胃黏膜屏障功能的机制之一。