目的：比较盐酸米诺环素软膏与碘甘油辅助治疗第三磨牙冠周炎伴牙龈脓肿的临床效果。方法164例患第三磨牙冠周炎伴牙龈脓肿的青年大学生患者，随机分为2组，每组82例，2组均行牙龈脓肿切开排脓、冠周冲洗上药、口服替硝唑、头孢拉啶和复方硼砂含漱液含漱等综合治疗，试验组冠周上质量分数2%的盐酸米诺环素软膏，每3天1次；对照组冠周上质量分数1%的碘甘油，每天1次。治疗3d后复诊，对比2组的疗效。结果试验组总有效率为93.9%，对照组为78.0%，差异有统计学意义（χ2=8.546，P=0.003）。2组均未发生药物不良反应。结论盐酸米诺环素软膏辅助治疗第三磨牙冠周炎伴牙龈脓肿可收到良好的临床效果。%Objective To compare the clinical effects of minocycline hydrochloride ointment (Periocline) and lo⁃dine glycerin as adjuvant therapy for pericoronitis with parulis. Methods 164 college students suffering from pericoro⁃nitis with parulis were divided into 2 groups randomly: observation group (82 cases) and control group (82 cases). All cases were treated with incision and drainage of the parulis, and then pericoronal rinsing. What's more, tinidazole and cefradine plus compound borax gargle mouthwash were given to them. 2% Periocline was filled into the periodontal pocket for the observation group (q3d) while 1% lodine glycerin was filled into the periodontal pocket for the control group (qd). Clinical effects of the two groups were observed and compared 3 days later. Results The effective rate of observation group (93.9%) was higher than that of control group (78.0%) with statistically significance (χ2=8.546, P=0.003). No drug adverse reaction occured. Conclusion It shows good effects when Periocline is applied as an adju⁃vant therapy for pericoronitis with parulis.
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